Essay On Silico Analysis Of FLT3 Gene - 1051 Words

In silico analysis of single nucleotide polymorphism (SNP) in human FLT3 gene ABSTRACT FLT3 is a member of extracellular receptors on hematopoietic precursors and belongs to the class 3 tyrosine kinase receptor. The FLT3 receptor is receptor gene encodes a 993-amino acid protein. Its location on the chromosome is 13q12. FLT3 receptor ligand , FL-like tyrosine kinase poisoning 3 receptor interaction works to maintain, spread and differentiate from the normal hematopoietic stem. The damaging mutations for FLT3 gene have not been predicted in silico. The current work was done to determine the harmful single nucleotide polymorphisms in FLT3 gene of Homo sapiens by Several bioinformatics tools to identify functional SNPs, predict damaging†¦show more content†¦In addition, FMS-like tyrosine kinase-3 receptor expressed in most acute lymphoblastic leukemia cells and acute myeloid leukemia(Drexler, Meyer et al. 1999). FMS-like tyrosine kinase-3 receptor mutations are identified in about 30% of the adult with acute myeloid leukemia, and leukocytosis and poor prognos is(Rasko, Metcalf et al. 1995, Kiyoi and Naoe 2002, D Kottaridis, Gale et al. 2003, Levis and Small 2003, Stirewalt and Radich 2003, Naoe and Kiyoi 2004, Kiyoi, Yanada et al. 2005). In normal bone marrow, expression appears to be restricted to early progenitors, includingCD34_ cells with high levels of expression of CD117 (c-KIT)(Rasko, Metcalf et al. 1995, Drexler 1996, Kiyoi, Yanada et al. 2005). FMS-like tyrosine kinase-3 receptor is also expressed at high levels in a spectrum of hematologic malignancies including 70% to 100% of myelogenous leukemia of all French-American British subtypes-precursor cell acute lymphoblastic leukemia , a fraction of T-cell acute lymphoblastic leukemia, and chronic myelogenous leukemia in lymphoid blast crisis(Mackarehtschian, Hardin et al. 1995, Kiyoi, Yanada et al. 2005). Targeted disruption of FMS-like tyrosine kinase-3 receptor in healthy adult mice with normal mature hematopoietic populations(Savvides, Boone et al. 2000). However, there are deficiencies in primitive B-lymphoid progenitors, and bone marrow transplantation experiments that show reduced ability of stem cells lacking FMS-like tyrosine kinase-3